The collaboration aims at enabling fermentation of sugar into 3HPA using a bioengineered microorganism. The 3HPA can subsequently be transformed into a range of valuable chemical derivatives including acrylic acid -- a high value, high volume chemical that goes into a broad range of materials including plastics, fiber, coatings, paints and super-absorbent diapers.

“Due to increasing oil prices, conversion of renewable raw materials to chemicals is becoming economically viable and holds significant commercial potential,” says Novozymes’ Executive Vice President Thomas Videbæk, who heads up the company’s BioBusiness division. “This strongly positions Novozymes to put its bioinnovation capabilities to work towards our vision of a ‘biobased economy’ where biomaterials will gradually replace many of the petroleum-based products we know today. The collaboration with Cargill is a good example of how we leverage and build upon our technology base to expand the business into new areas.”

Cargill, a leading supplier to the bioindustry globally, already has patents relating to biobased 3HPA. Novozymes will contribute its unique technological platform in protein and pathway engineering, i.e., targeting microorganisms to produce a desired compound. Both companies bring expertise in large-scale fermentation.

“Cargill is already a leading player in the conversion of renewables to chemicals,” says Jack Staloch, director of Cargill’s BioTechnology Development Center. “Based on the strong Intellectual Property position we’ve created, we see an opportunity together with Novozymes to make conversion of renewables to 3HPA and its derivatives such as acrylic acid a commercial reality.”

The scientific hurdles to be overcome are significant, both companies acknowledge, but they expressed confidence that their combined strengths put them in good positions to tackle the technology challenge. The companies expect the technology to be ready within five years, at which time it will be made available for others to produce and sell 3HPA and its derivatives such as acrylic acid.
Facts: 3HP and acrylic acid

In the process to be developed by Novozymes and Cargill, glucose or another carbohydrate source will be converted to 3-hydroxypropionic acid (3HPA) by fermentation. This conversion is a multi-step enzymatic reaction within the cells of the micro-organism. 3HPA from the fermentation can then be recovered and transformed into chemical derivatives, such as acrylic acid.

At present, the major source of acrylic acid is produced in the petrochemical industry by oxidation of propylene, a product from the refining of crude oil. Almost half of the 3.1 million tons of crude acrylic acid produced annually (2005) is used to make glacial acrylic acid for superabsorbents finding its major use in personal care items such as diapers (more than 1 million tons annually). The remainder is used to produce acrylates that are components of acrylic fibers, coatings, paints and inks